Diagnosis and Prognosis

In this section you will learn more about the various diagnostic techniques including the clinical, laboratory, morphologic, flowcytometric, cytogenetic and molecular factors influencing or reflecting individual prognosis of MDS.

Next Generation Sequencing in MDS
Next Generation Sequencing in MDS

Next Generation Sequencing in MDS by Dr. Austin G Kulasekararaj.

Dr. Austin G Kulasekararaj
Duration: 48 min. Added on: 01-04-2021.

Clonal evolution, complex karyotypes and TP53 in MDS
Clonal evolution, complex karyotypes and TP53 in MDS

Clonal evolution, complex karyotypes and TP53 in MDS by Dr. Detlef Haase.

Dr. Detlef Haase
Duration: 61 min. Added on: 01-04-2021.

Chronic Myelomonocytic Leukemia: Pathobiology and Prognostication
Chronic Myelomonocytic Leukemia: Pathobiology and Prognostication

Chronic Myelomonocytic Leukemia: Pathobiology and Prognostication by Dr. Patnaik.

Dr. Patnaik
Duration: 34 min. Added on: 01-04-2021.

Bone marrow histology in MDS
Bone marrow histology in MDS

Bone marrow histology in MDS by Dr. Leoni Saft.

Dr. Leonie Saft
Duration: 42 min. Added on: 01-04-2021.

Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Clinical Implications
Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Clinical Implications

Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Clinical Implications by Dr. David Steensma.

Dr. David Steensma
Duration: 18 min. Added on: 01-04-2021.

Diagnosis, prognosis and treatment of children with MDS
Diagnosis, prognosis and treatment of children with MDS

Diagnosis, prognosis and treatment of children with MDS by Dr. Yoshimi.

Dr. Yoshimi
Duration: 33 min. Added on: 01-04-2021.

New approaches to ineffective erythropoiesis in MDS
New approaches to ineffective erythropoiesis in MDS

New approaches to ineffective erythropoiesis in MDS by Dr. Platzbecker.

Dr. Platzbecker
Duration: 20 min. Added on: 01-04-2021.

Applications of FISH at diagnosis and management in MDS
Applications of FISH at diagnosis and management in MDS

Applications of fluorescence in situ hybridization (FISH) at diagnosis and management in Myelodysplastic Syndromes

Dr. Francesc Sole
Duration: 19 min. Added on: 24-11-2020.

Mechanisms of ineffective hematopoiesis in MDS
Mechanisms of ineffective hematopoiesis in MDS

Mechanisms of ineffective hematopoiesis in MDS presented by Dr. Norbert Gattermann

Dr. Norbert Gattermann
Duration: 33 min. Added on: 15-08-2019.

Genetic predisposition to MDS
Genetic predisposition to MDS

When should you consider an inherited syndrome? How many inherited syndromes are there? What types of mutations lead to these syndromes? How does malignancy develop in particular individuals? How do you provide long-term management for individuals with an inherited predisposition?

Dr. Lucy A. Godley
Duration: 42 min. Added on: 21-01-2019.

Molecular mutations update
Molecular mutations update

After the completion of this course, you will be able to recognise the most common recurrently mutated genes in MDS and the classes to which they belong. You will also be able to understand how mutations in normal individuals with CHIP differ from those seen in patients with MDS and CCUS and finally you will be able to identify the genes associated with prognostic significance that is independent of the IPSS-R.

Dr. Rafael Bejar
Duration: 35 min. Added on: 01-11-2017.

WHO 2016 update: Myelodysplastic syndromes
WHO 2016 update: Myelodysplastic syndromes

Review of the 2008 WHO categorization of MDS entities and the present 2016 changes in the updated classification based on recently accumulated data by John M. Bennett.

Dr. John M. Bennett
Duration: 28 min. Added on: 19-10-2016.

Flow cytometry
Flow cytometry

Arjan van de Loosdrecht is one of the global specialists in flow cytometry in MDS. He gives an introduction to the technique of flow cytometry and presents major findings in this field for patients with MDS.

Dr. Arjan van de Loosdrecht
Duration: 26 min. Added on: 16-07-2013.

Bone Marrow Histology in MDS
Bone Marrow Histology in MDS

In the most cases of MDS, bone marrow biopsy may provide additional information about marrow cellularity, fibrosis and CD34+ cell clusters. Specific phenomena like the ALIPS (abnormal location of immature precursors), which is associated with a negative prognosis, are detectable with biopsy.

Dr. Leonie Saft
Duration: 20 min. Added on: 09-06-2013.

Assessment of prognosis in MDS
Assessment of prognosis in MDS

The clinical course for MDS is variable and focuses on morphology type and prognostic parameters. There is a variety of clinical, laboratory, morphologic and cytogenetic factors influencing or reflecting prognosis. The scoring systems will be discussed as well as other new prognostic parameters.

Dr. Ulrich Germing
Duration: 12 min. Added on: 22-05-2013.

Cytogenetic Prognosis
Cytogenetic Prognosis

Cytogenetic analysis is not only necessary from the diagnostic point of view but enables us to get important prognostic and therapeutic information. The new cytogenetic risk groups will be explained in detail with special regard to cytogenetic abnormalities correlated with specific MDS-subtypes.

Dr. Detlef Haase
Duration: 13 min. Added on: 22-05-2013.

The use of molecular diagnostics in patients with MDS
The use of molecular diagnostics in patients with MDS

New publications indicated that mutation status in MDS might be clinically very important and in particular, that specific mutations predict survival independent of other variables. Mutations specific for some MDS-subtypes will be discussed as well as their clinical relevance.

Dr. Raphael Itzykson
Duration: 14 min. Added on: 22-05-2013.

Cytomorphology
Cytomorphology

The major morphologic characteristics of specific MDS-subtypes like MDS are presented and explained in detail by Professor Emeritus J.M. Bennett

Dr. John M. Bennett
Duration: 17 min. Added on: 15-05-2013.

FISH as a complement to conventional cytogenetics
FISH as a complement to conventional cytogenetics

The position of FISH as a complementary method to conventional cytogenetics in MDS patients by Dr. Francesc Sole.

Dr. Francesc Sole
Duration: 13 min. Added on: 15-05-2013.

Mechanisms of ineffective hematopoiesis in MDS
Mechanisms of ineffective hematopoiesis in MDS

Mechanisms of ineffective hematopoiesis in MDS presented by Dr. Norbert Gattermann

Duration: 33 min. Added on: 15-08-2019.

Molecular mutations update
Molecular mutations update

After the completion of this course, you will be able to recognize the most common recurrently mutated genes in MDS and the classes to which they belong. You will also be able to understand how mutations in normal individuals with CHIP differ from those seen in patients with MDS and CCUS and finally you will be able to identify the genes associated with prognostic significance that is independent of the IPSS-R.

Duration: 35 min. Added on: 01-11-2017.

Josep Carreras
Gustave Roussy / VUmc
UTZ
UMG
University of Rochster
Karolinksa